Transcriptomic analyses
Transcriptomics is a process to measure whether a gene is turned on or off in a cell. Transcription refers to the process where the information in the DNA is copied to produce an RNA transcript, a copy of the gene sequence.
This allows a cell to follow the instructions in the DNA and produce the gene. Based on the conditions of the cell (example whether it is healthy or sick), some genes can be produced in large amounts and some might not even be produced. By measuring the amount of these genes, we can identify which genes are involved in postoperative outcomes.
We can use these gene signals to predict the outcomes of CPB surgery. We can also use this information to develop novel diagnostics and intervention strategies. From the blood samples that were collected in the previous NITRIC study, we can perform these analyses.